I think the value of the upgrades depends a lot on use. It's actually rare to have a catastrophic failure on the 6.0 as long as you stop driving when things start going wrong. But, each failure can cost $3-4,000 per occurrence, and more importantly can interrupt a trip. If your travels are local, or are able to sit in a town for a couple weeks during repairs, maybe not the end of the world. For somebody like me, who can't even spare a single downtime day on long trips, the 6.0 is not a good option unless it has been Bulletproofed.
But, even after BulletProofing, there are still some sensors that can leave you dead on the side of the road.
Dodges have their own issues too though.
If I had a Ford 6.0, I'd probably just do a Cummins 5.9L conversion. The controls are so much simpler, things are just less likely to leave you stranded. And it doesn't have Navistar's terrible EGR system. It will play well with the Ford transmission, which has ample torque capacity to handle even highly-boosted 5.9's.
In fact, I've been tempted lately to pull the trigger on a 6.0 van lately (for destroking)because you can buy them for quite a bit cheaper than the equivalent V10 now! But, I don't need 2 vans in the driveway, and my V10 still gets the job done every time.