All of my 12VDC items that is controlled by the 12VDC Power Distribution Panel has two wires running to it usually from a 2-conductor marine grade cable. The Black wire is positive +12VDC and the White wire is negative -12VDC. Nothing that these DC cables control need to go to the actual trailer frame ground. Both the positive 12VDC and the negative 12VDC leads are terminated at the 12VDC Power Distribution panel where the fuses are located.
Mine looks like this
This is another pictorial on using my ON-BOARD Power Distribution Panel for wiring
When I am working with the batteries and battery switches etc then I do run some frame ground DC wiring, This is usually under the trailer or outside on the tongue area or maybe on the basement wall next to the front of the trailer.
My on-board Converter/charger and power distribution panel do have a frame ground cable installed. If I have an optional INVERTER installed inside the trailer than I will run a frame ground cable to it as well.
The point I am bringing here is all of the inside DC appliances and the lights etc all have a 2-conductor cable feeding them that is carrying both + and - 12VDC wires.
Just the high current paths around the battery banks may use the frame ground as an conductor...
This is the way my OFF-ROAD POPUP camper is wired at any rate...
Roy Ken