No worries about ABS wires or parts on the F150. All you have to do is jack it up, place your jackstands, remove tire and wheel, remove caliper and hang it up out of the way, and just pull off the rotor. It is captured by the wheel studs, wheel, and caliper. Make sure the rotor is clean, and slide it on. Remove old pads from caliper, free up and lube the caliper bolts and slides, replace the pads (right and left and inside and outside are all different, get it right....), replace the clips, put it back together.
Some people like to rough up the new pads with light sandpaper before install, I don't do that. I also never replace the brake fluid unless I had to break open that sealed system (rebuild calipers, master cylinder, replace line, etc), or if I had a zillion miles on the vehicle. The worst rotors I ever got were from O'Reillys, they lasted 2 weeks on a Lincoln Mark I had, they warped so bad.