People's experiences are almost always different. I have run with vents under MAXXAIR covers open and closed. I have had cross winds try to suck the driver's door open with the window rolled up and the TC loaded.
Leaving Denver, my son did not latch the escape hatch on the left side of my TC overhead. The wind sucked the window open with the latch lever banging around and the screen totally disappeared.
Wind velocity and direction variables can cause different reactions.
Roll the dice, take your chances. Life is short, don't let little things suck........