I've run 80psi front and rear according to the max inflation rating on the sidewalls. It does ride a bit rough, especially on Highway 101 South of San Jose, but that's just California's mismanaged Highway system at fault...
I've always inflated all of my vehicles to the maximum or within 5 to 10 psi of the max rated pressure on the sidewall. Right now I'm running 80psi on an 80psi max tire. The suspension is what is designed to absorb the bumps, using your tires to accomplish that is compromising safety for comfort in my humble opinion. I will grant that if your running 65psi on a max 80psi tire your fine but if your running 40psi on an 80 psi tire with a loaded vehicle you might be taking on unnecessary risk.
Will a problem arise? Likely not but if I hit one of California's signature freeway swallow my truck type potholes with 5000lbs in the bed, doing 70mph, I'd much rather have a high pressure tire that is ready for the abuse than a half pressure tire and risk a pinch flat or a damaged rim.
I also ride with about 30psi in the Airbags as well. It isn't necessary really on my dually and sometimes I try without or go up to 60psi just to see how it feels. I do this to reduce rolling on curvy roads or to ensure my lights aren't blinding drivers at night.