blackgrizz550; you ask opinions on this forum and you will receive them. You wish to compare the F150 5.0 and the Tundra 5.7, both very capable and reliable vehicles. Mileage empty will average mid to upper teens and pulling will be around 9 for both trucks. Any difference measured over a year will buy you a 16 ounce coke. Reliability over 200 thousand miles will be about the same. Ford along with GM and Ram have been building working trucks for a long time and they make them very well.
Any measurable differences between the trucks are going to be subjective, ride, ease of entry and exit, beauty, dealer convenience and of course, price. Pick the one you and your family like the best and enjoy it. You won't go wrong with either choice.