We have not made this trip before and are wondering if the here is a way there more favorable/wiser than the other. It will be either north across 80, 70, or 30. All routes show extremely close miles....
80 isn't bad, but in case you didn't know, Ohio is FLAT. As in FLAT like a Pancake. (Until you get over near Youngstown anyways...) So the scenic last 6-8 hours of your trip home would be nothing but corn stubble. (Blech!!)
Personally, I'd stay south through Columbus. I've crossed that way heading towards North Carolina (and will be again next week, in fact!) and it was a pretty decent ride.