Gear ratio advice 3:73 or 4:30 on Super Duty

I am in the beginning stages of looking for a new TV and was looking at the Fords to start off with. (Dont worry Dodge fans I will look at them next) I see that Ford has either the 3:73 or 4:30 gears for what I would be interested in, 4wd, dually, crew cab. Currently my fiver is only 11k but all the new ones we look at are in the 16K range so I am looking to future proof myself a bit. My truck is also my daily driver.

My question is what gears would you recommend. Will I notice any big changes in MPG? We are currently weekend campers with one/two longer trips a year, but in the next 5-6 yeas that might change to more longer trips.

There is a 3K towing difference between the 2 gears but honestly if I am getting something that weighs 26k I will probably get a MDT.

Any advice?