Is it ok to drive a truck with a bad coil / spark plug?

Second what Bryan said. I have an 06 4.6 Explorer with 225 k miles and dealt with more misfires that I care to remember. You do not wash the cylinder, the injectors do not get power when there is no spark. Drove hundreds of miles with a misfire when it happened on a family trip (no towing), and since changing the plugs on my 3 valve is not something you can do on a parking lot, I drove it home with OD off to keep rpm high and just keep going. Nothing happened to the engine.