Most of the high points have been hit, but I'll add my 2 cents. The Isuzu trucks imported into our country are really not intended for freeway towing and are better suited for around town. Engine specs are a 5.2 liter inline-4 with 215 hp and 452 torque, about the same as a stock older Dodge Cummins. Ok power but not even close to modern pickups. Transmission is an Aisin, which is not really a big deal since Aisin builds more transmissions than any other company. The 11K rear axle and 16K GVWR puts the NPR XD crew roughly equal to the F450, although it's 22K GCWR is lower due to having only half the power and torque.
So, if you have a lawn maintenance business and need to haul 4 guys around town and pull an equipment trailer, the NPR is a great choice. I see them all the time in this application. For pulling an RV, not so much.