As long as you're not over the tire weight ratings... I'd run it!
The axle/housing itself (not posted by Ford) has a weight rating that approaches five-figures. You could always move something from the truck to the rear of the trailer, or from the front of the trailer to the rear.
As with anything, the more you load it the sooner it will wear out. You will reduce the life of the outer bearings, but their life is already being reduced due to the fact that you are carrying a load heavier than an empty truck bed.
I wouldn't sweat it one tiny bit!