For a smooth, quiet ride, I've always been extremely satisfied with Michelin LTX. I've owned 3 sets on 1/2 ton trucks and got 65,000 to 80,000 miles on all 3 sets.
I never took them off road, so I can't speak for that. Anytime we ever experienced any serious winter snow/ice, I would set a 700 lb crate of steel (borrowed from work) in the bed over the rear axle. With the added weight in the rear, my truck felt as safe as anything I've ever driven on snow & ice. And that is comparing it to my son's AWD Subaru Outback with dedicated winter tires.
My two highest priorities in tire performance are normally wet weather traction and a smooth quiet ride. I find the reviews at tirerack.com very helpful in seeing which tires score well in these two categories. I would recommend you take a look at their tire reviews before you decide.
My current 2015 2500HD is still running the factory Goodyear Wrangler SR-A tires in size LT265/60R20. I would give them very high marks for the smooth, quiet, comfortable ride they provide. They still look like new with 15,000 miles on them. I've been in a couple of blinding rain storms pulling a trailer and they have handled it well.
All in all, I have no complaints with the Goodyear Wrangleer SR-A tires.