I like truck campers for the ability to fit just about anywhere. Other than that, Trailers and 5th wheels are easier to hook/unhook and are more comfortable overall. I think I actually get the same or less mileage with a TC due to high wind resistance relative to a travel trailer. 5th wheel is by far the easiest to hook and unhook and use your tow vehicle as a touring vehicle.
Truck campers are easier on cross country trips when stopping to eat/fuel/shop etc. by a large margin, and one of the primary benefits. Good luck.
Gman