Too many miles on truck before long trip?

I have a 2008 3/4 ton, GMC with 180k miles. HATE the thought of replacing it any time soon, but am I crazy to try and plan a 10k cross-country road trip towing our 5'er?
-Tony

If it has gone 180,000 miles with no major issues, the statistics are in your favor that it will go another 10,000 miles with no major issues. As stated above, do some preventative maintenance before the trip.

Even if you have to fix something on the road it will likely be far less expensive than a new truck.