Too many miles on truck before long trip?

I traded a perfectly good running and looking '05 Ram 2500HD with 120k miles on it for the same reason you fret over taking a trip. Reality is, there was absolutely nothing wrong with the Ram and someone got a like new truck for $9k~. Not even a door ding. I followed it's whereabouts after trade in hopes it got a good home. I like our current F250 but I definitely didn't "need" a new truck. If there's nothing about your truck that's giving you any indication there's trouble brewing, I would say enjoy your trip. Our F250 now has 86k on it and I have no doubt about it going another 200k with proper maintenance and an occasional repair.