I can drive long distances, have done it many times. I usually do it like Bid time, drive while the others sleep. At night, there is less traffic.
One thing I noted, you plan to drive US2 a majority of the way. Wrong, get on I-94 and put the cruise on. Minnesota has the nicest rest stops in the country but there is little else to see so that 240mi, shot from Mpls, MN to Fargo, ND is a 65 mph conveyor belt. Same for everything from Fargo to the turn off for US 2 at Glendive, MT.
Happy travels and go easy.