Towing with a 3.73 F250 6.2L, will a 4.30 axle help ??

Hey guys....... I have a 2011 F250 Crew Cab SB, 4WD Lariat with 6.2L and 3.73 E-locker. Running 5-Star tuner on it, helps with the throttle-lag and gets true WOT when you put the pedal down. Also...