My opinion--yours may vary.
Ford and GM both modified their engines to be rated for 0% to 20% biodiesel in 2011. I believe that Ram Cummins went a few more years before that rating. B5 is generally thought to run in anything and Mercedes Van diesel carried that rating for a long time, maybe still. 2% to 4% biodiesel is thought to be very good for lubrication.
There have been many debates on the differences between F-250 and F-350. For single rear wheel vehicles, the only difference since 2012 Job 2 has been the price, the auxiliary spring in the rear, the chrome badge on the side, the spacing block on the rear axle (F-250 had 2" while F-350 had 4") and the VIN sticker. The weight rating is intentionally down rated to 9900 or 10,000 on F-250s so that some folks can get cheaper insurance and license tags. The early 2010 1/2 model of the 2011 F-250 may have used a lighter weight axle left over from the prior year--since then the axles have been the same. Sometime around the middle of the decade, Ford starting putting in taller spring spaces blocks so the F-250s don't squat under load as much as they used to. So late model F-250s can be upgraded to carry a heavier load with air bags, and many do that.