After years of running to TPA pretty much along this route we have come to prefer and are partial the Columbus 520/82 to Albany--- then GA 133 on the east side of Albany off US 19 (Doe Run, east side of Moultrie, Berlin, Morven) down to I-75 at Valdosta.Nice ride through cotton and peanut farms of south GA.
To us its a bit more direct than the Dothan/ I-10 alternative.The roads we've listed here are all great. The Columbus route seems a bit less hilly- there are a few small rolls from Ft Benning to Richland but nothing of significance).
We've run this route for 40 years- even before the 520 super slick was built. We've made the run down to central FL along this way with motorhomes (x3), TT's (x2), a TC and a fiver. We like the ability to hit the large commercial pull offs along the way in Columbus, Dawson, Albany, and Moultrie. Look for fresh pecans