Those are commonly used secondary routes for truckers. There are no restrictions for motorhomes on them. There are a few hills and curves, but it's all quite workable for most any vehicle and certainly a small class C motorhome. (You might be a bit slow on some of the hills, but I assume you're somewhat used to that already.) I don't know specifically of current construction, etc. concerns but would not expect significant problems, and for sure there would be reasonable detours suitable for large vehicles as needed.
A hint: when going from I-87 to I-90, pay attention to keep to the righthand lane. The righthand of the two lanes that exit for I-90 is also a merge lane from the previous interchange, and pretty soon after the exit from I-87 this righthand lane has the I-90 West entrance split off from it (and both exit lanes continuing on for I-90 East). The signs don't give a whole lot of warning for the I-90 West lane specifically, and merging over quickly can be tricky if there's much traffic.