Well I wouldn't do it but my DH grew up in Lynchburg and says tractor trailers go that way.
From the parkway to Natural Bridge is curvy but not as bad. You can take 122 from Bedford to 501 which is a pretty drive. You can take 29 to north of Lynchburg then 130 west until it joins 501 just past the parkway.
Depends on where you are coming from and if Natural Bridge is your ultimate destination.
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