Drive it all the time but it is boring. Not interesting at all. Taking US 395 through the Ownes Valley is one of the great motoring roads in America.
If you are adventerous take one of the roads through Death Valley. If not take Highway 6 over Montgomery Pass.
Once you get to Reno keep going up to Susanville, CA and then take Route 44 to McCloudCA the old logging town and pick up Interstate 5 near there. It is the back way but a really great road through forests with views of Mt Lassen and Mt Shasta.