S. Carolina Aquarium - yes. Also check out the H. L. Hunley at the Warren Lasch facility in N. Charleston. Usually only open on weekends (the conservators work on it during the week) it is (to me anyway) a fascinating piece of history. If you're there, check out Sesame Burger (just a bit further north) for an incredible selection of burgers and beer.
We've been to both Hyman's & Bubba Gump's. The former has a more extensive selection of seafood but the quality of both is good.
If the weather cooperates a bit, check out Magnolia Plantation.
