We use the slide supports on ours. We live in a semi permanent location and don't plan on moving much. We are on a concrete slab, have 6 support jack stands under the frame for stability. We have custom made bunk beds in the slide so we wanted the extra support. I don't worry about a flat tire as the jack stands would not let it come down anyway. And we are in it all the time. Just make sure you use them as directed. We check ours about every 3 months just to make sure they are still snug.
It really depends on how you are using your RV. If we were just going campground to campground I would not use them.