I'm going to take a different position from most. I used to tow a Keystone Raptor 35.5' with a Dodge Ram 3500 DRW 4WD and carried a HD motorcycle in the back. Now traveling with the 07 Itasca Horizon 40'DP, hydra lift for the M/C and towing a Jeep. In my opinion, driving the truck was less fatiguing than the motorhome. Setting up each has it's peculiarities and if an overnight in a pull through site, the motorhome is easier as I don't even need to get out to level, boards required for there 5th wheel.
When traveling with the toy hauler, the bike arrived clean, not so with the motorhome and lift, but I have tons of more room in the motorhome. Back to driving, we could carry on a conversation in a normal voice. ALL motorhomes are noisy driving, some far more than others, because a box going down the road isn't very aerodynamic and sound proofing just not possible unless spending perhaps millions on one.
There are advantages to each but in many ways I miss the truck and 5th wheel. If I were put in the position to have to replace the RV setup completely, I would consider going back to the truck/5th wheel toy hauler combo.
That said, I enjoy driving the motorhome and getting everything ready to travel or "camp" for the night or week is easy.
2007 Itasca Horizon 40FD
2012 Jeep Wrangler Sahara
2015 Harley Davidson FLHTKL