We have a Forest River 2501TSF on a Ford E-450 chassis. Our experiences are as follows:
Power, it's very apparent that the Ford 7.3 is much more powerful than the Chevy. Also, power will increase substantially at about 7500 miles.
Center consul heat, we haven't noticed this issue; possibly as the 7.3 engine is much narrower than the previous 6.8 V10.
Alignment, all of the new RV's need alignment as when Forest River adds 9000# to the chassis, the partial cab alignment changes. Forest River doesn't state this but they will pay up to $300 for an alignment. We had the tools and $35 for one camber/caster bushing, so we did it ourselves. Have them set it for zero toe-in/toe-out, otherwise the steering will feel vague.
Gas mileage, we have an average of 9.8 mpg over the last 4000 miles driving around 67 mph, without towing.
Leg Room, the Chevy is better. Also, some people don't like the Ford driver's seat. For me both are ok.
Other: U-Haul and RTD prefer Ford chassis so maybe they are more reliable. We purchased from RV Wholesalers vs Camping World manly for price, and we pleasantly surprised by how well their warranty service worked vs Camping World. Also add the Forest River Bilstein Shocks, Helwig rear sway bar package, it's well worth it.