Tommy47, I can relate to your issues and maybe contribute some information that may help.
I owned a 1990 Rockwood class C on an E350 Ford chassis with a 460 7.5 ltr engine.
The chassis was manufactured in 1989, the first year Ford put Fuel injection on that motor. In cold weather it ran fine but in the summer It would loose power on hills to the point of stalling the engine. If I let it set for 20 minutes it would start right up and run and pull normally until the next hill.
After talking with some local knowledgeable mechanics they told me that Vapor Lock on a fuel injected motor was rare but not impossible. First suggestion was new fuel pump. That helped but did not completely solve the issue.
Next (if you have the same motor) look on the drivers side below the drivers door, mounted to the frame rail you will find a black canister. It looks like a smaller oil filter. Ford calls it a "Fuel Delivery System" They put it on some Early Ford 460's. it simply UN-screws like a oil filter but it has a fuel filter inside (The first of two). Go to an auto parts store and get another filter, it will be in a box with a new "O" ring gasket. Open the box and throw the filter away and use the new gasket (make sure the old one is removed) and reassemble the canister without the filter. Just ahead of this is the second fuel filter just inside the frame rail, replace this one with a new one.
This solved my problem and here is my opinion on the issue. The motor was simply running out of gas when hot. I believe and one of the Ford technicians would not Deni that the Fuel Delivery System was just a small reserve of fuel when engine demand was greatest. All pumps do work better when they are cool.
Now on the Over Heat issue, I would leave the standard 190 degree Thermostat alone. The gauges on a 1990 model are not the "smart" gauges we now have. The gauges on vehicles of that era would respond to variations with a wide range. On my 1990 460 the standard after warm-up was mid-way. Going up a hill or in a pull 3/4 way was normal. Around town and stop and go Mid-Way on the gauge was normal. Down the interstate in summer at 60 mph 3/4 way all the time. I get to town it is back mid way. If you notice the Oil pressure gauge( after warm up) shows a wide range depending on idyl vs take off.
If you have the same motor I hope this helps, it is from experience and the 460 is a proven motor despite what the engineers were forced to do to it because of the EPA and emissions testing.
Ron
A wonderful Wife
Two kids, 7 Grand kids
1997 Class C 31' Four Winds, Towing 1997 Jeep Wrangler 4 down.