We have not made this trip before and are wondering if the here is a way there more favorable/wiser than the other. It will be either north across 80, 70, or 30. All routes show extremely close miles....
Have never done that but have done MA to Defiance OH enough and from Defiance we have gone to Fort Wayne. Route 24 is so nice now and I just looked at bing maps and it had you coming 24 to 475 to I 80 into PA getting to 76 and then heading off to DC. Good luck.