Too many miles on truck before long trip?

I have 193k on my little 2006 Explorer with 4.6 v8, and since I have had it for the past 6-7 years and know every piece of it, and what was replaced and or not, I do not hesitate and just hook up the trailers I pull with it and go, maybe not 10k, but if you know your truck, I would not worry.
The way I look at it, if your particular truck was made on a "good" day, and it has gone 180k miles without major issues, then it will go another 100k. If they mess something on an assembly line because it was Monday, or just after holidays or something else, then you would have issues before you hit 100k.