I have taken my jacks off but it was solely to prevent possible damage in a very gnarly, snotty-muddy, rutted off-road situation one time in a late season hunt when several inches of snow came down and I had to get up and out of a valley.
If I had slipped off one of the ruts into the side embankment it would have damaged the camper whereas without the jacks it might have only damaged some of the truck body. I was picking the lesser of two evils... thankfully no damage to anything as 4WD low and chains on all four kept me on the straight, steep and narrow.
But I put those jacks inside the back of the cab! If OP is considering taking off the jacks for saving weight, then my story does not apply.
When it comes to camper jacks, it is better on the road to have and not need them as opposed to the verse-visa. JMHO.
Sold the TC, previous owner of 2 NorthStar pop-ups & 2 Northstar Arrows...still have the truck:
2005 Dodge 3500 SRW, Qcab long bed, NV-6500, diesel, 4WD, Helwig, 9000XL,
Nitto 285/70/17 Terra Grapplers, Honda eu3000Is, custom overload spring perch spacers.