Its pretty steep on the downhill side going into NC and has quite a few sharp turns. Going up from G'burg is still steep and some sharp turns with ample room to make it. You better know what you're doing to take it on. Every time I have gone over the mountain I have seen RV's from A's to C's to trailers and even cars with their brakes burned up. A diesel with an exhaust brake system is the best but if you don't have that you better know your limits and how to use your tranny gears.
What is your destination? If its Cherokee then I would go I-40 to exit 20, rt.276 to NC19 and go in that way. Its still steep in a couple places but not near as bad as 441.
If its points further south go to exit 27, Rt 74, the Smoky Mtn Expressway to hook up with 23. I take this route when we go to FL and like a lot better than 75.