Best route from Lander WY to Charlotte NC

You can get snow that time of year on most routes unless you get down to I-20 or farther south which is way out of your way. We hit snow on I-40 in April more than once. I would watch the weather and take I-80 to I-29 down to Rt 36 across Missouri.Then I-72 to I-74 to I-75 to I-40.Make sure you have a snow shovel, chains and Good Sam's or some other type of road service and be prepared to hole up for a day or 2.

IF you run I-40 in to NC. Were I you. I would catch I-26, and run it to I-85, and then in to Charlotte.

^^^What he said.

But DO be prepared for snow on I-40. It can get ugly. Not Wyoming ugly, but still bad. Keep an eye on the weather forecasts and be prepared to stop somewhere an extra day or 2 as needed. The good news is that snow and ice usually doesn't stick around more than a couple of days in this part of the world.

Also there is so much traffic on I-40 that one pile-up can keep you stuck for many many hours. Be prepared with plenty of gas, blankets, food, water, and TP in the tow vehicle.

Lander to Casper, Casper on ( I25 ) South to ( I 40 ) Left turn and go East JMHO