I'm a bit confused...how do you take 95 from Ohio to Florida (or from Ohio to anywhere)? :h Upon reflection, I guess you must mean mainly in Florida—basically whether to stick to the ocean or the gulf side.
I personally would prefer I-75, but that's mainly because I'd get to visit my mom who is now living in Ft. Myers. Even though she's a wonderful lady, that's probably not of great interest to you for your trip.
Ft. Desoto, a county park in St. Petersburg, has a beautiful campground, some nice beaches, kayaking, biking, etc. It can sometimes be a bit hard to get into; reservations are a good idea, though I think I remember seeing that they do reserve some sites for first-come, first-serve use.