Parking the truck in San Francisco

I used to travel a lot to San Fran for work. I know one time I made the mistake of renting a Tahoe (it was the only car National had at the time). Even that was a PITA to park. And I remember the hotel charging something outrageous for parking (like $50+/night) because it was oversized.

I wouldn't want to try to do a lot of touring with a full size truck. I would rent a car for the day. Enterprise will usually give you a pretty good daily rate if you are in law enforcement, military, insurance industry, etc.