Only thing that is going to change is pin box mounting holes and hitch height.
5vr is still going to have same bed rail clearance
To increase bedrail clearance and tow level you have to raise the 5th wheel at axles AND then make adjustments to pin box and/or hitch
(leaf springs moved to top of axles IF under----'axle flip', relocate leaf springs in shackles IF you have adjustment holes, a subframe channel lift OR use the 'Correct Track Kit' By LCI----aligns axles BUT raises 5vr 2")
How much bedrail clearnace to you presently have?
6"
Less
More
Trimming back corners of pin box has been done on many to increase pin box clearance for tight off slanted turns
Provided 5vr overhang clearance to bedrail is at least 6"