The thing I would advise is to check your medical insurance carefully and make sure you can use it in any state while traveling.
Also, since you enjoyed tenting, I feel you would have no issues finding a RV that your truck could pull. Not everyone needs a huge space for full-timing. We've seen it done happily in very small rigs.
I also agree that your wife should know how to drive the rig. That can put both of you at ease.
...and DO check out Escapees and their home-owned parks and co-ops. We especially like their Benson, AZ park for winter. It can get cool there and perhaps a light dusting of snow occasionally but it suited us just fine. It's 40 miles east of Tucson with terrific medical facilities. You'll meet friendly, helpful folks through the parks. They also have a good forum. Good luck!