I am 63 years old and not made of muscle, yet I have only a little trouble managing our 2007 E350 steel wheeled tires. I weighed one on our bathroom scale which came to 83 pounds. I replaced 4 of the 6 steel wheels with Alcoa alloy wheels which weigh 20 pounds less making them 63 pounds each.
Our 6 ton bottle jack that came with the rig is easy to manage but hard to pump up without adding an 18" gas pipe. I once thought of upgrading it with a 12 ton jack until I seen the size and weight of it. It is way more than our 24 foot long E350 rig requires.