The only occasional problem I'm aware of with the early R100 transmissions Ford used with the Triton V10 engines was an occasional check valve failure in the transmission cooler bypass line on the side of the body that led to overheating. The quick and easy fix was to just crimp the steel bypass line so the fluid always went through the cooler. The longer fix was to buy a set of bypass eliminator fittings and remove the bypass completely. In 2003 Ford eliminated the bypass. With the exception of doing the bypass crimp about 5 years ago and replacing the starter a couple of years ago, our 2001 F53 V10 equipped motorhome has performed quite well for about 65,000 miles.