As 35 year resident of Colorado and many year veteran of the I70 winter wars, I can speak with some confidence. You have a significant chance of being delayed that time of year by weather. Here are some tips:
1)Avoid the weekend ski traffic going west bound out of Denver on Friday evening and Saturday morning and east bound out of the mountains on Sunday afternoon. If you don't follow this piece of advice, you will regret it. Picture rush hour in the mountains during the winter, add some snow and a few jackknifed semis, below zero temperatures, and traffic at a standstill for hours.
2)Plan your trip to go through Vail Pass/Eisenhower Tunnel during the late morning or early afternoon hours.
3)Be sure to watch the conditions east of the Denver area. Often the eastern plains are far worse than the mountains due to blizzards.
4)We personally stop in the Fruita/Grand Junction area when headed east bound. You can access the weather and road conditions before heading out and hit the mountains at my suggested times. I'm sure others can suggest timing from the east headed west.
5)Don't get in a hurry and just be prepared to stop for 24 hours. Being from Quebec you don't need winter RV advice. Interstate closures are usually only for a few hours but can last 24 hours or better upon occasion.
6)The most reliable road conditions including real time cameras can be found at
Colorado Department of Transportation. The local Denver television media tend to get a bit hysterical when it comes to winter storms and are not always the best source of information. Channel 4 is probably the most reliable. AM radio stations 630, 760 and 850 offer road condition updates a couple times an hour.
7) Some may suggest dropping down to I40. That will sometimes work depending on the storm path. But it can be a real bugger in its own right in New Mexico and Arizona.