Most vehicles have interior light switches on the dash. If you leave that switch ON and allow the vehicle to 'auto turn off' the interior light after you lock the door, then that switch could create a significant amp draw while a vehicle is parked. Make sure that switch is OFF.
If you are experiencing a battery drain situation, the first thing you should do is make sure you have a good battery and not be assuming its good because its relatively new. I have had floating shorts in batteries.
P.S. my DW has already hammered me with floating short jokes , she beat you to it :B .
A 20-50milliamp draw is normal, a 1 or 2 amp draw is not.
The next thing to do, put a multi-meter on the battery to see exactly how many amps or milliamps are flowing with the engine off , vehicle parked with no key in the ignition , remove the key ! and make sure the vehicles door is closed !!
Pull fuses one at a time from the multiple panels in your vehicle so you can isolate the circuit.
*Remember to keep the vehicles door closed or tape off the door switch to make it inoperative.
* Once you hook up the multi-tester to test amp flow, all your vehicles 12v power is going thru that meter.
You might want to disconnected it from the battery when you open the vehicle door so you don't flood your meter with a sudden burst of amps and burn it out.