Ford V10 vs Pending V8

I suspect you won't ever see a significant chassis front-end redesign on the E series platform. If Ford were to spend money to make large changes to the basic chassis, it would be far more sensible for them (from a corporate bean-counter point of view) to put the resources into an improvement or variant of the Transit chassis. The E series is rather a legacy product; it's still being built because a fair few people are buying them and the basic engineering has been long amoritized so it doesn't cost too much to keep making them. Updates are made to it mostly to get rid of things that are unique to it, hence changing the engine and transmission and dashboard to be more common with the F series.

If the new engine is narrower than the V10, you might find a little more foot space in the cab. I don't know offhand if it's narrower or not.