In many of the gas vs. diesel discussions, you need to consider which specific chassis you are considering. With the Ford E series you will get a mileage increase but not a huge one. Power will be around the same, since both the 7.3 and 6.0 Powerstroke engines are derated to in the neighborhood of 250 hp/440 torque. The V10 IIRC is 305/425. Longevity is not a factor because the coach should fall apart long before the engine,and both the 7.3 PS and V10 are durable, long lasting engines. The 6.0, although better in the E series than the pickups, has reliability issues that would erase it from contention if I were shopping.