8-ish on the interstate is probably a reasonable guess; at that length, you're not likely to be talking of a diesel motorhome.
Weight has some effect on the mileage, but not as much as you might expect for highway driving; once you're moving, it doesn't affect the rolling resistance much and affects the air resistance not one bit. It does, of course, affect the mileage when going up hills or in stop-and-go/city driving where one's speed isn't steady.
(Incidentally, most gas class C motorhomes also get around 8-ish mpg.)