Our 2012 E-350 24' Nexus {54,000 miles} rides and handles just fine. The only thing I have done was to replace the original shocks at 33K miles with heavy duty Bilsteins which made an incredible difference {Huge improvement}.
I barely feel passing tracks and an am comfortable driving in 35 mph winds. What works for me and I guarantee will work for anyone else is to properly inflate your tires for the load they are supporting. IGNORE the max pressure on the sidewalls and IGNORE any preprinted stickers found in the coach. They might, just maybe, be right but it is not likely.
Get your rig weighed, inflate per the tire manufacturers load/inflation tables and if you still have issues look to get an alignment with the proper {likely increased} caster. Nothing further should be needed, just replace anything that wears out {like shocks} with quality gear engineered for the job you are asking them to perform.
As always... Opinions and YMMV?
:C