We traveled full-time for 16 years with no slide problems and yes, we were able to access everything with them closed. Since we enjoy forest campgrounds and boondocking in the boonies we sought out a RV with only two slides and both had to be on the same side of the RV. Having opposing slides would have made it very difficult to situate the RV in many places because of trees on both sides. The more slides you have the less bay storage and easy access you'll have. They also add weight. Good luck in your search!