I installed a TPMS system after driving home to Cincinnati from south of Lexington and found the next day that an outside dual had zero air pressure and a large spike in the tread. It didn't shred or affect the other dual. I have no idea where I picked it up, but it scared me enough to add the TPMS system. Now I have a monitor right there on the dash.
Only other flat was when some idiot backed into the left front tire of my toad. Oh, wait. The idiot was me. :)