I've used seafoam in lots of things with never a problem EXCEPT one. And that one problem sure took a long time to find. Mine (Ford) started throwing misfire codes. The causes of mis-fire codes goes on forever. Started working my way through them.
Spark plugs that are damaged or worn
Spark plug wires and/or coils that are damaged or worn
Distributor cap that is damaged or worn (only if applicable to the vehicle)
Rotor button that is damaged or worn (only if applicable to the vehicle)
Fuel injectors that are defective
EGR valves or tubes that are clogged
Ignition timing that is off
Vaccum leaks
Fuel pressure that is low
Head gasket(s) that are leaking
Distributor cap that is cracked
Camshaft sensor that is faulty
Crankshaft sensor that is faulty
Mass air flow sensor that is faulty
Oxygen sensor that is faulty
Throttle position sensor that is faulty
Catalytic converter that is faulty
PCM is faulty changed fuel filter
That list took me (a back yard DIY guy) lots of time.
Long story short...Most all injectors have what's called "micro mesh fuel injector bucket. Think of them as a filter for you injector, that is real tiny. Take a look here so we are same page
https://www.google.com/search?q=micro+mesh+injector+bucket&biw=1301&bih=589&source=lnms&tbm=isch&sa=X&ved=0ahUKEwizlNrPka7QAhVhl1QKHTdzAT8Q_AUIBygC#tbm=isch&q=micro+mesh+fuel+injector+bucketMy best guess to what happened to me after putting in some seafoam.
New fuel filter I put in was defective or the Seafoam cleaned out something that was stuck in the fuel tank and that mess made it way forward. Either metal filings from drilling the hole for the generator fuel line. Or when made in 03 at OEM. At any rate the seafoam freed them up. Then the filings were made it to the fuel filter, it plugged it up. Most filters have a "bypass mode" so if filter gets plugged up you can keep going. The metal filings then made it pass fuel filter to the injector buckets creating mis-fire codes.
What I would do...
I would run it, but if it keeps running rough change fuel filter. And carry a spare filter. But if it throws any "mis-fire" codes after you change fuel filter I would check out those injector "buckets". Injectors on mine are about $80.00 each so I took mine out and used a magnafying glass and good light to pick those small things out injector by injector. Then after all back together did it twice again when traveling. I think because maybe some more filings maybe worked their way thru that were stuck inside the fuel line tubing and worked themselves free. So might help to flush out entire fuel line from filter to motor.
I got so good at change out an injector I could do it in about 20 min and I still carry a spare fuel filter and injector.
Beyond that one time, always pleased how seafoam worked.