Seafoam was invent back in the 30s (?) To reduce carbon build up in 2 stroke outboards (back then they would mix 24:1 or richrecommendser). Primary active ingredient is napthw.
Gumout makes multiple different fuel additive that have different chemicals so they ARE DIFFERENT !
A "friend of a friend" actually is a chemist in the fuels and lubes industry. For a "fuel system cleaner" he recommends anything with polyether amine (PEA). The most common PEA additive is Techron, but some Gumout products also have PEA.
"Top Tier" fuel should be all you need. When I towed, I did use Premium fuel going through mountains, mostly for peace of mind.
E10 fuel does NOT reduce the effectiveness of either. Those additive do nothing to prevent fuel icing.