It does not matter what type of RV you have, pop-up to behemoth bus, everything needs to be packed away when on the road.
I did once leave a C-size battery sitting on end, on the counter. Drove about 3 hours before the first stop. Got out, checked the inside of that camper and that battery was just sitting there ... unmoved!
But last Friday we were on the road, drove only 25 miles, and in that short time, 2 cabinet doors popped open and stuff fell out on the floor! How do you figure that?
Your best bet is to make sure everything is put away, in some kind of a container in the cabinets where, even if the door opens, it still will not fall out! (I'm getting a couple more small baskets for those 2 cabinets now!
How long to feel comfortable with your new rig? About 3 trips!