We've been lucky so far. Have only had one flat on the RV in 20 years or so. The one we had was in a bad place on US 58 in VA with a 2 foot wide shoulder and a ravine. First thing I did was call the State Police non 911 number and ask for a block. They transferred me to the local Sheriff dispatcher and I had the block not 5 minutes later. So a shout out to Suffolk VA for the great department they have.
I found a Discount Tire store about 30 miles up the road and bought 2 new tires. TPMS did alert but it was too late, whatever I hit sliced the tire good.
This was a very new to us 5er at the time. I found out that the spare on the road side would not come out the access door on that side, I had to crawl thru from the door side to get it out. Something to check on some 5ers with the spare in the storage area.
Also this 5er has the axles mounted under the axles whereas the former Jayco had the axles mounted above the springs. Make sure if you use a ramp it will get the flat off the ground. I had to use leveling boards to make that happen.
Like someone else said, practice in your driveway. My ramp worked great on the Jayco when I was doing brake/bearing maintenance.